| Characteristic | Description |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Form | Chewable Tablets |
| Dosage | 100 mg |
| Use | Treatment of Erectile Dysfunction |
| Contraindications | Heart Conditions, Nitrates |
| Interactions | Antihypertensives, CYP3A4 Inhibitors |
| Toxicity | Vision Changes, Hearing Loss |
| Prescription | Yes |
| Visit Kamagra Polo Site | |
Chemical Structure of Sildenafil
The active compound in Kamagra Polo is Sildenafil Citrate. This molecule has a complex structure. It consists of a pyrazolo-pyrimidinone core. The presence of a piperazine ring is notable. A sulfonamide group further enhances its pharmacological properties. The structure facilitates binding to phosphodiesterase type 5 (PDE5) enzymes.
Sildenafil’s affinity for PDE5 inhibits its action. This leads to increased levels of cyclic guanosine monophosphate (cGMP). Elevated cGMP results in smooth muscle relaxation. This action is critical for treating erectile dysfunction (ED). The molecular formula is C22H30N6O4S. Its molecular weight is 474.58 g/mol.
The pharmacokinetics of Sildenafil is noteworthy. It has a bioavailability of about 41%. Maximum plasma concentration is reached within 30 to 120 minutes. Metabolism occurs primarily in the liver. It involves the CYP3A4 enzyme system. The elimination half-life is approximately four hours.
Kamagra Polo Use in Erectile Dysfunction
Kamagra Polo 100 mg is employed in the management of erectile dysfunction. ED affects millions globally. Sildenafil enhances blood flow to the penis. This facilitates achieving and maintaining an erection. The chewable form ensures rapid absorption. This is beneficial for quick onset of action.
Kamagra Polo is typically taken as needed. It should be consumed 30 to 60 minutes prior to sexual activity. It is not intended for daily use. Maximum recommended frequency is once daily. This dosage should not be exceeded to avoid adverse effects.
Patients report improved sexual performance. Psychological benefits also occur. Confidence and satisfaction often increase. Kamagra Polo offers a practical solution for many men.
Kamagra Polo Contraindications
Several contraindications exist for Kamagra Polo 100 mg. It is unsuitable for individuals with certain heart conditions. This includes severe cardiac failure. Patients on nitrates should avoid Kamagra Polo. The combination may cause severe hypotension.
It is contraindicated in those with severe liver impairment. Patients with hereditary degenerative retinal disorders should exercise caution. These include retinitis pigmentosa. Those allergic to sildenafil or similar compounds must not use Kamagra Polo.
A medical consultation is vital before initiation. This ensures safe and effective use. It is imperative to consider individual health conditions. This minimizes risks and optimizes outcomes.
Kamagra Polo Interactions
Interactions with other drugs are possible. Sildenafil 100 mg may interact with antihypertensives. This can lead to an excessive drop in blood pressure. Combining with CYP3A4 inhibitors alters its metabolism. This includes medications like ketoconazole and erythromycin.
Concomitant use with alcohol is not advisable. It may exacerbate adverse effects. Grapefruit juice impacts drug metabolism. It can increase sildenafil plasma levels. This interaction enhances the risk of side effects.
Patients must disclose all medications to healthcare providers. This includes prescription, over-the-counter, and herbal products. Such discussions help manage potential interactions. It ensures optimal treatment efficacy and safety.
Toxicity Concerns with Sildenafil
Toxicity is a concern with improper use. Overdose of Kamagra Polo 100 mg can lead to serious effects. Common issues include vision changes. Sudden hearing loss is another possibility. These symptoms necessitate immediate medical attention.
Priapism is a rare but serious condition. It involves prolonged and painful erection. Left untreated, it may result in permanent damage. Cardiovascular complications are also possible. This includes myocardial infarction or arrhythmia.
Regular medical supervision is crucial. Monitoring ensures appropriate dosage and use. Patients should adhere to prescribed guidelines. This minimizes risks and enhances therapeutic benefits.
Is Non-Prescription Kamagra Polo Available?
Kamagra Polo is a prescription medication. It should be obtained through a licensed healthcare provider. The requirement for a prescription ensures proper patient evaluation. This assessment confirms the suitability of the drug.
Non-prescription availability raises safety concerns. Self-medication can lead to adverse events. It is crucial to involve a healthcare professional. They provide guidance on correct usage and dosage.
Access to legitimate sources is important. Counterfeit products may not be safe. They can contain harmful substances. Patients should exercise caution when purchasing online. Authenticity and safety should be prioritized.
Data source:
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